- Original Article
- The neuroprotective effect of mycophenolic acid via anti-apoptosis in perinatal hypoxic-ischemic brain injury
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Ji Young Kim, Seung Ho Yang, Sun Hwa Cha, Ji Yeun Kim, Young Chae Jang, Kwan Kyu Park, Jin Kyung Kim, Hai Lee Chung, Eok Su Seo, Woo Taek Kim
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Clin Exp Pediatr. 2007;50(7):686-693. Published online July 15, 2007
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Purpose : Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is a potent inhibitor of inosine-monophosphate dehydrogenase (IMPDH), a new immunosuppressive drug used. It was reported that MPA protected neurons after excitotoxic injury, induced apoptosis in microglial cells. However, the effects of MPA on hypoxic-ischemic (HI) brain injury has not been yet evaluated. Therefore, we examined whether MPA... |
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- Case Report
- A Case of Anti-Neutrophil Cytoplasmic Antibodies (ANCA) Positive Wegener's Granulomatosis
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Won Tae Kim, Woo Jeong Kim, Joon Sik Kim, Chin Moon Kang, Kwan Kyu Park
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Clin Exp Pediatr. 1994;37(8):1175-1181. Published online August 15, 1994
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Wegener's granulomatosis is a disease of unknown etiology that is characterized by the clinicopathologic complex of necrotizing granulomatous vasculitis of the upper and lower respiratory tract, glomerulonephritis, and variable degrees of small vessel vasculitis. Recently Antineutrophil Cytoplasmic Antibody (ANCA) has been reported to be a highly specific test for the diagnosis of Wegener's granulomatosis.
We have experienced a patient of Wegener's... |
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